In addition, encapsulated compounds are also easier to handle. Encapsulating agent can be served as a protector coat against adverse environmental condition resulting in the increased stability. However, encapsulation has been reported to be an effective way to introduce such substances into the mentioned products. Since polyphenolic compounds including anthocyanins have low stability toward environment condition during processing and storage, it is a hard task force to incorporate the mentioned substance into foods and health products. Recently, it has been demonstrated that the substances which are rich in polyphenolic compounds especially anthocyanins can improve both metabolic syndrome and cognitive impairment. Therefore, this problem should be concerned and the successful strategies for combating this condition are required. Moreover, the current therapeutic strategy is still not in satisfaction level. Unfortunately, less information concerning this issue is available. Based on the rising trends of both menopause and metabolic syndrome mentioned earlier, the memory impairment in menopausal women with metabolic syndrome is increasing its importance and is recognized as one of the important health problems. Moreover, both menopausal condition and metabolic syndrome can induce memory impairment and decrease hippocampal plasticity. Recently, it has been demonstrated that the prevalence of chronic diseases including metabolic syndrome in menopausal women is increased. The number of menopausal women is continually increasing worldwide.
#IKWETFLOOR MME EFFECT TRIAL#
However, further research especially clinical trial is still necessary. Therefore, MME is the potential novel neuroprotectant and memory-enhancing agent for menopause with metabolic syndrome. Therefore, the neuroprotective and memory-enhancing effects of MME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in hippocampus. It was found that MME decreased memory impairment, oxidative stress status, and AChE activity but increased neuron density and Erk phosphorylation in the hippocampus.
Spatial memory together with neuron density, oxidative stress status, acetylcholinesterase, and phosphorylation of Erk in the hippocampus was assessed at the end of the study. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required.
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